M.G. Nichols and R. Hallworth. Review of: Confocal and Two-Photon Microscopy: Foundations, Applications and Advances, edited by Albert Diaspro. Wiley-Liss, New York, NY. Microscopy and Analysis, May, 2004.

Book Chapters

M.G. Nichols, K. Ward, L. Zholudeva , H. Jensen-Smith, R Hallworth.  Autofluorescence Lifetime Imaging.  Natural Markers for Cellular Metabolism: Biology, Techniques, Applications, V. Ghukasyan and A. Heikal (eds.), Series in Cellular and Clinical Imaging, CRC Press, Boca Raton, FL, September 2014.

JP Anderson, JG Williams, DL Grone, MG Nichols. Metal Enhancement of Near-IR Fluorescence for Molecular Biotechnology Applications. Chapter in Reviews in Fluorescence 2009. C. Geddes (ed.),  Springer,  New York, 2011. p 1-22. 

H. Jensen-Smith, B. Currall, D. Rossino, L. Tiede, M. Nichols, and R. Hallworth. Fluorescence Microscopy Methods in the Study of Protein Structure and Function.  Chapter in Molecular Techniques in Auditory & Vestibular Research, B. Sokolowski (ed.), Methods in Molecular Biology series, Humana Press, 2008.

Refereed Publications


I. Meerovich, M. G. Nichols, A.K. Dash. Lipid-based nanoparticles for addressed delivery of paclitaxel with controlled induction of drug release by near-infrared light illumination of low intensity. Journal of Drug Targeting. Accepted - In Press (Submitted September 10, 2018).

D.E. Desa, M. G. Nichols, H. J. Smith. Aminoglycosides rapidly inhibit NAD(P)H metabolism increasing reactive oxygen species and cochlear cell demise. J. Biomed. Opt. 24(5), 051403 (2018), doi: 10.1117/1.JBO.24.5.051403.

S.V. Prathivadhi-Bhayankaram, J. Ning, M. Mimlitz, C.Taylor, E. Gross, M. Nichols, J. Guck, and A. E. Ekpenyong. Chemotherapy impedes in vitro microcirculation and promotes migration of leukemic cells with impact on metastasis. Biochem. Biophys. Res. Comm. 479:841-846, 2016. PMID: 27687547

LV Zholudeva, KG Ward, MG Nichols H Jenson Smith. Gentamicin differentially alters cellular metabolism of cochlear hair cells as revealed by NAD(P)H fluorescence lifetime imaging," J. Biomed. Opt., 20(5), 051032 (2015).

R. Hallworth, K. Stark, L. Zholudeva, B. Currall, and M.G. Nichols. The Conserved Tetrameric Subunit Stoichiometry of Slc26 Proteins. Microsc Microanal 19:799-807 (PMC3767988), 2013. Free PMC Article

J. Vergen, C. Hecht, L. V. Zholudeva, M.M. Marquardt, R. Hallworth, M.G. Nichols. Metabolic imaging using two-photon excited NADH intensity and fluorescence lifetime imaging. Microsc Microanal 18:761-70 (PMC3842212), 2012. Free PMC Article

R. Hallworth, M.G. Nichols. The Single Molecule Imaging Approach to Membrane Protein Stoichiometry. Microsc Microanal 18:771-80 (PMC3786598), 2012.  Free PMC Article

H.C. Jensen-Smith, R. Hallworth, M.G. Nichols. Gentamicin rapidly inhibits mitochondrial metabolism in high-frequency cochlear outer hair cells. PLoS One 7:e38471 (PMC3371036), 2012. Free Open Access Article

R. Hallworth, M.G. Nichols.  Prestin in HEK Cells is an Obligate Tetramer. J. Neurophysiol 107:5-11 (PMC3349699), 2012. Free J. Neurophysiol Article

J. Tonniges, M. Hansen, J. Duncan, M.J. Bassett, B. Fritzsch, B.D Gray, A. Easwaran, M.G. Nichols. Photo- and bio-physical characterization of novel violet and near-infrared lipophilic fluorophores for neuronal tracing. J. Microscopy, 239: 117–134, 2010.

A.E. Ekpenyong, C.L. Posey, J.L. Chaput, A.K. Burkart, M.M. Marquardt, T.J. Smith, and M.G. Nichols. Determination of Cell Elasticity through Hybrid Ray Optics and Continuum Mechanics Modeling of Cell Deformation in the Optical Stretcher. Appl. Opt. 48, 6344-6354 (PMC3060047), 2009. Free PMC Article

L. Tiede, P.S. Steyger, M.G. Nichols, R. Hallworth. Metabolic Imaging of the Organ of Corti – A Window on Cochlea Bioenergetics. Brain Res. 1277: 37-41 (PMC 3044933), 2009. Free PMC Article

L.M. Tiede, S.M. Rocha-Sanchez, R. Hallworth, M.G. Nichols, and K. Beisel. Determination of hair cell metabolic state in isolated cochlear preparations by two-photon microscopy. J. Biomed. Opt., 12, 021004 (PMC1992521), 2007. Free PMC Article

R. Hallworth, B. Currall, M.G. Nichols, J. Zuo. Studying Inner Ear Protein-Protein Interactions Using FRET and FLIM. Brain Res. Rev., 1091:122-131 (PMC1992439), 2006. Free PMC Article

L. Tiede and M.G. Nichols. Photobleaching of reduced nicotinamide adenine dinucleotide and the development of highly fluorescent lesions in Rat Basophilic Leukemia cells during multiphoton microscopy. Photochem. Photobiol. 82:656-664, 2006.

V.A. Matei,  F. Feng, S. Pauley, K. Beisel, M. Nichols, and B. Fritzsch. Near-infrared laser illumination transforms the fluorescence absorbing X-Gal reaction product BCI into a transparent, yet brightly fluorescent substance. Brain. Res. Bull. 70:33-43, 2006.

E. Barth, R. Hallworth and M.G. Nichols. A comparison of the sensitivity of photodamage assays in rat basophilic leukemia cells. Photochem. Photobiol. 81:556-562, 2005.

M.G. Nichols, E. Barth and J.A. Nichols. Reduction in DNA synthesis during two-photon microscopy of intrinsic nicatinimide adenine dinucleotide fluorescence.  Photochem. Photobiol. 81:259-269, 2005.

C.E. Bigelow, D.L. Conover, T.H. Foster, I. Georgakoudi, C.J. Harkrider, S. Mitra, M.G. Nichols and M. Rajadhyaksha. Retrofit design and implementation of confocal scanning using a commercial inverted fluorescence microscope platform. Rev. Sci. Inst. 72:3407-3410, 2001.

G.L. Indig, G.S. Anderson, M.G. Nichols, J.A. Bartlett, W.S. Mellon and F.Sieber. Effect of molecular structure on the performance of triarylmethane dyes as therapeutic agents for photochemical purging of autologous bone marrow grafts from residual tumor cells. J. Pharm. Sci. 89:88-99, 2000.

E.L. Hull, M.G. Nichols and T.H. Foster. Quantitative broadband near-infrared spectroscopy of tissue-simulating phantoms containing erythrocytes.  Phys. Med. Biol. 43:3381-3401, 1998.

E.L. Hull, M.G. Nichols and T.H. Foster. Localization of luminescent inhomogeneities in turbid media using spatially-resolved measurements of cw diffuse luminescence emittance.  Appl. Opt.  37:2755-2765, 1998.

I. Georgakoudi, M.G. Nichols and T.H. Foster. The mechanism of Photofrin photobleaching and its consequences for photodynamic dosimetry. Photochem. Photobiol. 65:135-144, 1997.

M.G. Nichols, E.L. Hull and T.H. Foster. Design and testing of a white light steady-state diffuse reflectance spectrometer for determination of optical properties in highly scattering systems.  Appl. Opt. 36:93-104, 1997.

M.G. Nichols and T.H. Foster. Oxygen diffusion and reaction kinetics in photodynamic therapy of multicell tumor spheroids.  Phys. Med. Biol. 39:2161-2181, 1994.

T.H. Foster, D.F. Hartley, M.G. Nichols and R. Hilf. Fluence rate effects in photodynamic therapy of multicell tumor spheroids. Cancer Res. 52:1249-1254, 1993.


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